Inclusion criteria
- Age ≥ 60years and ≤ 75 years
- AML as defined by WHO
- Refractory anaemia with excess of blasts (RAEB)
- primary and secondary AML
- First complete remission following one or two cycles of induction chemotherapy, according to current participating cooperative group protocols
- Karnofsky score > 70% (see appendix D)
- Written informed consent
Exclusion criteria
- AML FAB M3
- Organ dysfunction
- Patients with creatinine clearance < 50 ml/min
- Cardiac ejection fraction < 40%
- Severe defects in pulmonary function testing (defects are currently categorized as mild, moderate and severe) as defined by the pulmonary consultant, or receiving supplementary continuous oxygen
- Liver function tests: total bilirubin > 2x the upper limit of normal, SGOT and SGPT 4x the upper limit of normal
- Karnofsky score < 70% (see appendix D)
- Patients with poorly controlled hypertension
- HIV positivity
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