Originele protocol

Inclusion criteria

  • Age ≥ 60years and ≤ 75 years
  • AML as defined by WHO
  • Refractory anaemia with excess of blasts (RAEB)
  • primary and secondary AML
  • First complete remission following one or two cycles of induction chemotherapy, according to current participating cooperative group protocols
  • Karnofsky score > 70% (see appendix D)
  • Written informed consent

Exclusion criteria

  • AML FAB M3
  • Organ dysfunction
    • Patients with creatinine clearance < 50 ml/min
    • Cardiac ejection fraction < 40%
    • Severe defects in pulmonary function testing (defects are currently categorized as mild, moderate and severe) as defined by the pulmonary consultant, or receiving supplementary continuous oxygen
    • Liver function tests: total bilirubin > 2x the upper limit of normal, SGOT and SGPT 4x the upper limit of normal
  • Karnofsky score < 70% (see appendix D)
  • Patients with poorly controlled hypertension
  • HIV positivity


Klik hier voor flowschema.